信号转导和转录激活因子(signal transducer and activator of transcription, STAT)是一大类具有细胞质内信号转导和细胞核内转录激活双重作用的蛋白，广泛存在于哺乳动物细胞中，介导多种细胞内信号通路。

The signal transducer and activator of transcription (STAT) is a family of intracellular cytoplasmic transcription factors involved in many biological functions in mammalian signal transduction.

STAT3是一种在多种组织中表达的信号分子。STAT3参与细胞增殖、分化、凋亡和炎症反应等多种生物学过程。然而，STAT3在大多数人类癌症中变得过度激活，通常与不良的临床预后有关。

Among them STAT3 is involved in cell proliferation,differentiation,apoptosis and inflammatory responses, and also STAT3-related signaling pathways are a barren over-activated in many types of cancer and are strongly associated with poor patient prognosis.

肿瘤微环境（TME）中肿瘤细胞内STAT3过度激活会介导一系列细胞外信号，增强肿瘤微环境的免疫炎症反应，驱动肿瘤细胞增殖、侵袭和转移，同时强烈抗肿瘤免疫反应并创造免疫抑制微环境。

Excessive activation of STAT3 within tumor cells and other cells in the tumor microenvironment (TME) mediates a series of extracellular signals that enhances the immune inflammatory response in a TME, driving tumor cell proliferation, invasion, and metastasis, while strongly suppressing the anti-tumor immune response and creating an immunosuppressive microenvironment.

研究表明，持续激活的STAT3对于多种癌症是必不可少的，比如乳腺癌和结直肠癌，这使得STAT3成为理想的药物靶点。

Studies have indicated that persistently activated STAT3 is indispensable for various cancers including breast cancer and coleractal cancer ,which makes it an ideal drug target.

南宫NG·28可提供STAT3药物发现、CMC研究（API+制剂）、药效研究、PK研究、安全性评价等一站式研发服务。

Medicilon provides STAT3 drug discovery, CMC Research (API + formulation), pharmacodynamics research, PK study, safety evaluation and other services.

STAT3药物靶点研发服务

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